To improve therapeutic responses in patients with glioma,new combination therapies that exploit a mechanistic understanding of the inevitable emergence of drug resistance are needed.Intratumoral heterogeneity enables a low barrier to resistance in individual patients with glioma.We reasoned that targeting two or more fundamental processes that gliomas are particularly dependent upon could Targeting Ferroptosis New Hope for As-Yet-Incurable Attaining control over life and death decisions facilitates the identification of new therapeutic strategies for diseases affected by early cell loss or resistance to cell death.In this context,ferroptosis,a prevailing form of non-apoptotic cell death marked by the iron-dependent oxidative destruction of lipid bilayers and metabolic aberrations,has attracted overwhelming interest among Target Discovery and Validation Methods and Strategies Target Discovery and Validation Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation.With contributions from noted industry and academic experts,the book addresses the most recent chemical,biological,and computational methods.
Title:TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis VOLUME 25 ISSUE 40 Author(s):Sally E.Dickinson* and Georg T.Wondrak* Affiliation:Department of Pharmacology,College of Medicine and The University of Arizona Cancer Center,University of Arizona,Tucson,AZ 85724,Department of Pharmacology and Toxicology,College of Pharmacy and TheStrategies for Molecular Imaging of Epidermal Growth A wealth of research has focused on developing targeted cancer therapies by specifically inhibiting epidermal growth factor receptor tyrosine kinase (EGFR-TK).However,the outcome of most EGFR-TKtargeted drugs that were approved by the Food and Drug Administration or entered clinical trials has been only moderate.Enhancement of EGFR-targeted therapy hinges on a reliable in vivo Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456Next
antioxidants.This article will examine the strategies of antioxidant de- fense in biological systems.Emphasis will be more on identi- fying the types of antioxidants or the principles of defense,rather than on reviewing the available literature.For further information,the reader is referred to [3-71 which concen-Redox-dependent induction of antioxidant defenses by Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and,therefore,for preventing diseases and achieving healthy aging.Fruits,vegetables,and spices contain a wide variety of hormetic phytochemicals,which may explain the beneficial health effects associated with the consumption of these dietary components.Redox regulation in tumor cell epithelialmesenchymal Aug 18,2017 molecular strategies for targeting antioxidants to#0183;To this end,destroying a fine-tuned antioxidant system with specific inhibitors or inducing excessive levels of ROS beyond the antioxidant capacity of cancer cells could be attractive strategies
Aug 18,2017 molecular strategies for targeting antioxidants to#0183;To this end,destroying a fine-tuned antioxidant system with specific inhibitors or inducing excessive levels of ROS beyond the antioxidant capacity of cancer cells could be attractive strategies Quercetin as an innovative therapeutic tool for cancer Sep 30,2019 molecular strategies for targeting antioxidants to#0183;Mechanism of Cancer Chemoprevention An Overview.Chemoprevention is based on the idea that cancer is a progressive disease and various signaling pathways and molecular events associated with cancer development can be targeted for therapeutic intervention 21.Cancer development has been divided into three distinct stagesinitiation,promotion,and progression (malignantProteomic and Systematic Functional Profiling Unveils Acinetobacter baumannii has been reported as a multidrug-resistant bacterium due to biofilms and antimicrobial resistance mechanisms.Hence,novel therapeutic strategies are necessary to overcome A.baumannii infections.This study revealed that citral at 200 g/ml attenuated A.baumannii biofilms by up to 90% without affecting viability.Furthermore,microscopic analyses and in vitro assays
Researchers have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease.The findings could lead to new strategies Possible new treatment strategy for fatty liver disease Researchers have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease.The findings could lead to new strategies Oral Antiviral Blocks Transmission,Multi-Organ Failure Dec 11,2020 molecular strategies for targeting antioxidants to#0183;Oral Antiviral Blocks Transmission,Multi-Organ Failure Mechanisms,Molecular Target for Lung Fibrosis COVID-19 Updates December 11,2020 Plus New biomedical data sharing platform,disrupting cholesterol processes may combat COVID-19,and a new project aims to understand formation of coronaviruses.
Many studies suggest that dozens of natural compounds,including polyphenols,can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes.Therefore,Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy.Nrf2 as molecular target for polyphenols A novel Many studies suggest that dozens of natural compounds,including polyphenols,can supress oxidative stress and inflammation through targeting Nrf2 and consequently activating the antioxidant response element-related cytoprotective genes.Therefore,Nrf2 may provide a new therapeutic target for treatment of diabetic retinopathy.Non-Hodgkin's B-cell lymphoma advances in molecular Non-Hodgkin's B-cell lymphoma advances in molecular strategies targeting drug resistance Exp Biol Med (Maywood).2013 Sep;238(9):971-90.doi 10.1177/1535370213498985.Epub 2013 Aug 28.Authors Steve A Maxwell 1 ,Seyed Mousavi-Fard.Affiliation 1 Texas AM Health
Mutations in PS-1 and PS-2 primarily alter the specific APP C-terminal cleavage site of the -secretase complex,favoring production of A 142.7 Thus,a set of therapeutic strategies emerged based on newly discovered proteases as targets stimulation of -secretase,inhibition of -secretase,and inhibition of the -secretase complex.8,9 The ability of a subclass of muscarinic receptors toNRF2 targeting a promising therapeutic strategy in Antioxidant / detoxification gene TRENDS in Molecular Medicine Figure 2.The regulation of NRF2-mediated antioxidant and detoxification gene transcription in response to oxidative stress.(i) Under basal conditions,KEAP1,an adaptor for the CUL3 E3 ubiquitin ligase,directly binds NRF2,thereby targeting it for destruction by the proteasome.Monoclonal antibody-based molecular imagingmolecular imaging as they facilitate the emission of a signal specifically from the target site,which is in turn detected by the various imaging modalities.Imaging probes generally consists of two parts a signal agent (e.g.radionuclide) and a targeting agent (e.g.mAb) that binds to
Tumor-associated macrophages (TAMs) are a promising therapeutic target for cancer immunotherapy.Targeted delivery of therapeutic drugs to the tumor-promoting M2-like TAMs is challenging.Here,we developed M2-like TAM dual-targeting nanoparticles (M2NPs),whose structure and function were controlled by -peptide (a scavenger receptor B type 1 (SR-B1) targeting peptide) linked with M2pepMolecular-Targeted Immunotherapeutic Strategy for Melanoma A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages.Journal of Crohn's and Colitis 2019,13 (4) ,Molecular structure analyses suggest strategies to Jun 10,2020 molecular strategies for targeting antioxidants to#0183;In addition to targeting components of the viral attachment and the membrane fusion machinery,other strategies to eliminate SARS-CoV-2 include
molecular strategies for targeting antioxidants to#0183;Lipophilic cations show great potential for the successful delivery of antioxidants to mitochondria; however,they present several disadvantages (i) limited capacity (only low-molecular-weight molecules and electrically neutral chemicals can be successfully transferred); (ii) sublocalization (these compounds tend to localize in the mitochondrial matrix and the matrix-facing surface of IMM; thus,the targetingMolecular mechanisms of hypertension--reactive oxygen Molecular mechanisms of hypertension--reactive oxygen species and antioxidants a basic science update for the clinician Although clinical trials failed to show beneficial antihypertensive effects of antioxidants,strategies that combat oxidative stress by targeting Noxs in an isoform-specific manner may have therapeutic potential.Molecular Targets and Strategies for Inhibition of the The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections.Pathogens utilizing a T3SS are responsible for millions of infections yearly.Since many T3SS knockout strains are incapable of causing systemic infection,the T3SS has emerged as an attractive anti-virulence target for therapeutic design.The T3SS is a multiprotein
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a hereditary cancer syndrome in which affected individuals are at risk for development of cutaneous and uterine leiomyomas and an aggressive form of type II papillary kidney cancer.HLRCC is characterized by germline mutation of the tricarboxylic acid (TCA) cycle enzyme,fumarate hydratase ( FH ).Molecular Insight into the Therapeutic Promise of Review Article Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimers Disease Abdullah Al Mamun ,1,2 Md.Sahab Uddin ,1,2 Md.Fahim Bin Bashar,3 Sonia Zaman,1 Yesmin Begum,1 Israt Jahan Bulbul,1 Md.Siddiqul Islam,1 Md.Shahid Sarwar ,4 Bijo Mathew,5 Md.Shah Amran,6 Ghulam Md Ashraf,7,8 May N.Bin-Jumah ,9 Shaker A.Mousa ,10 and Mohamed M.AbdelMolecular Insight into the Therapeutic Promise of Alzheimers disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction.Most of the AD cases are late onset,and the apolipoprotein E ( APOE ) isoform is a key genetic risk factor.The APOE gene has 3 key alleles in humans including APOE2 ,APOE3 ,and APOE4 .Among them, molecular strategies for targeting antioxidants tolt;i molecular strategies for targeting antioxidants togt;APOE4 molecular strategies for targeting antioxidants tolt;/i molecular strategies for targeting antioxidants togt; is the most potent genetic risk factor for late-onset AD (LOAD
Aug 19,2015 molecular strategies for targeting antioxidants to#0183;To establish a rational molecular design for bisphosphonate (BP)-modified proteins for efficient bone targeting,a pharmacokinetic study was performed using a series of alendronate (ALN),a nitrogen-containing BP,modified proteins with various molecular weights and varying degrees of modification.Four proteins with different molecular weightyeast glutathione reductase (GR; MWMitochondriatargeted antioxidants - Oyewole - 2015 - The In addition to addressing the concerns surrounding current antioxidant strategies,including difficulties in targeting antioxidant treatment to sites of pathologic oxidative damage,we discuss promising therapeutic agents and new strategic approaches.Oyewole,A.O.,BirchMachin,M.A.Mitochondriatargeted antioxidants.Mitochondrial dysfunction and oxidative stress in heart Dec 19,2019 molecular strategies for targeting antioxidants to#0183;Importantly,there has been increasing evidence that strategies targeting global ROS activity,such as trials with systemic administration of the antioxidants vitamin C
Apr 05,2019 molecular strategies for targeting antioxidants to#0183;Mitochondrial targeting using positively charged molecules that insert into the inner mitochondrial member appears to be deleterious in pancreatic acinar cells,as does an antioxidant strategy for the treatment of acute pancreatitis.PMCID PMC6480340 PMID 30959771 [Indexed for MEDLINE] MeSH terms.Acetylcysteine/pharmacology; Acinar Cells/drug effectsMitochondria and Antioxidant Targeted Therapeutic For this reason,targeting oxidative stress and mitochondria in AD may lead to the development of promising therapeutic strategies.Several exogenous antioxidant compounds have been tested and found beneficial in transgenic AD mice,such as vitamins and spices.However,their efficacy was much more modest in human trials.Hydrogen Therapy A Preventive Strategy for Better HealthAug 12,2019 molecular strategies for targeting antioxidants to#0183;Molecular hydrogen targets free radicals known to accelerate oxidative stress and inflammation,said Dr.Trainor.Hydrogen actually works at the genetic level,Trainor explains.It
Aug 12,2019 molecular strategies for targeting antioxidants to#0183;Essentially,when these antioxidants target damaging free radicals,they manage to shut them down and slow cellular injury.In the near distant future,Johnson predicts that H2 will be considered High-throughput drug screening identifies compounds and Our investigation into the mechanism of VRC2 implicated MDM2 inhibition and p53 pathway activation as molecular strategies for targeting PI-resistant cells,findings that directed us toward the FGFR3 targeting strategies for achondroplasia Expert Here we review the clinical features,genetic aspects and molecular pathogenesis of achondroplasia and examine several therapeutic strategies designed to target the mutant receptor or its signalling pathways,including the use of kinase inhibitors,blocking antibodies,
report the development of a molecular biosensor for rapid detection of antioxidant-responsive element (ARE)-bound Nrf2 protein.The development will provide a molecular assay for high-throughput screening of chemopreventive compounds.Specifically,a double-stranded DNA probe is designed based on the ARE sequence.One of the DNA strands is Cited by 2Publish Year 2019Author Jane A Armstrong,Nicole J Cash,Jack C Morton,Alexei V Tepikin,Robert Sutton,David N CriddleProspects for the introduction of targeted antioxidant EXPERT OPINION Effective antioxidant therapeutic strategies should include the design of protocols for the inhibition of OST through iron chelation,administration of synthetic and natural antioxidants and enhancement of the antioxidant defences by increasing the production of endogenous antioxidants and activation of antioxidant mechanisms.Cited by 18Publish Year 2010Author Ronald Carnemolla,Vladimir V Shuvaev,Vladimir R MuzykantovStrategies to target mitochondria and oxidative stress by Strategies to target mitochondria and oxidative stress by antioxidants key points and perspectives Pharm Res .2011 Nov;28(11):2771-9.doi 10.1007/s11095-011-0587-2.
Mitochondrial dysfunction is a core feature of acute pancreatitis,a severe disease in which oxidative stress is elevated.Mitochondrial targeting of antioxidants is a potential therapeutic strategy for this and other diseases,although thus far mixed results have been reported.Cited by 102Publish Year 2015Author Nadezda Apostolova,Victor M.VictorTargeting Antioxidant and Antithrombotic Biotherapeutics Use of SOD and catalase for antioxidant interventions was proposed almost four decades ago.66 However,their medical utility is precluded by rapid elimination and inadequate delivery to target cells.67 Diverse modifications of SOD and catalase including coupling with polyethylene glycol or other chemicals and encapsulation into liposomes have been designed to solve this problem (Table 2).6870 Some ofBreast Cancer Prevention,Detection Targeting Molecular In addition,several new natural compounds and combination therapies,including low molecular antioxidants,nucleic acids,and peptides,have demonstrated efficacy in targeting P53 and other related molecular markers,which is a breakthrough in naturopathic oncology.
An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate.Antioxidant compounds act through several chemical mechanisms hydrogen atom transfer (HAT),single electron transfer (SET),and the ability to chelate transition metals.The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants,their possible uses An overview of active and passive targeting strategies to It is however important to point out that active targeting strategies are still highly needed for the delivery of fragile bioactive molecules such as peptides,proteins and especially nucleic acids.Thus,novel targets and ligands could represent a major interest in this field.(DOC) Molecular targeting and drug delivery system for Virosome 9.Nanoparticle STRATEGIES OF DRUG TARGETING 1.Passive Targeting Drug delivery systems which are targeted to systemic circulation are characterized as Passive delivery systems.In this technique drug targeting occurs because of the bodys natural response to physicochemical characteristics of the drug or drug carrier system.